Stanford Medicine-Led Research Identifies New Method to Anticipate Initial Organ Failure

January 06, 2024

A recent study led by scientists at Stanford Medicine presents a straightforward approach to investigating organ aging by scrutinizing specific proteins or sets of proteins in blood samples, enabling the anticipation of individuals' disease risks. Involving 5,678 participants, the research indicates that organs age at varying rates. When an organ demonstrates advanced aging compared to its counterparts in individuals of the same age group, it elevates the risk of associated diseases and mortality for the person harboring it.

Approximately one in every five reasonably healthy adults aged 50 or older carries at least one organ exhibiting a significantly accelerated aging process. Using existing technologies and a custom algorithm, researchers assessed thousands of proteins in participants' blood, pinpointing nearly 1,000 organ-specific proteins. Abnormal levels of these proteins were linked to accelerated aging and heightened susceptibility to diseases and mortality in corresponding organs.